The number of antibiotic-resistant bacteria is on the rise all over the world. This poses a growing threat to the effective treatment of infections and places a significant burden on health systems, including Switzerland’s. In order to ramp up the fight against antibiotic resistance, the Federal Council adopted the new One Health Action Plan for StAR 2024-2027 as part of the Swiss Antibiotic Resistance Strategy (StAR) at its meeting on 26 June 2024. This Action Plan promotes effective measures, sets out national objectives and takes innovative approaches to ensure the long-term availability and effectiveness of antibiotics to preserve human and animal health.